Cook Inlet Region, Inc., also known as CIRI, is one of twelve land-based Alaska Native regional corporations created by the Alaska Native Claims Settlement Act of 1971 (ANCSA or the Act).

The Act addressed the aboriginal claim to land by Alaska Native people by mandating the formation of for-profit corporations representing various regions of the state and by providing land and seed capital to those corporations. CIRI is one of those corporations, with regional boundaries that roughly follow the traditional Dena’ina territory of southcentral Alaska. CIRI was incorporated on June 8, 1972.